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ActivitiesAssociate Professor Nishikata has developed a new method of selective fluorination by using inexpensive alkaline fluoride, and it has been published in Angewandte Chemie (IF=11.709). 2016.09.08

Fluorine is an essential element for useful compounds owing to its singular properties. For example, it is in fact contained in 20 to 30% of pharmaceutical products and agricultural chemicals. Consequently, development of efficient reactions for the fluorination of molecules is one of the most important issues in organic synthesis.

This time, Associate Professor (tenure track) Takashi Nishikata and colleagues at the Graduate School of Sciences and Technology for Innovation (Applied Chemistry Field) found that when they fluorinated a substrate that had multiple carbon-bromine bonds in the presence of a copper catalyst, the reaction proceeded selectively at the tertiary alkyl part. It is assumed that the mutual interactions between copper fluoride and amide generated during the reaction achieve selective fluorination. A characteristic of this reaction is also the fact that cesium fluoride can be used as the source of fluorine, which is less expensive than reagents that have been developed in the past.

The research results were published in “Angewandte Chemie, International Edition” (IF=11.709), adorning the inside cover as a piece of highlight research.

As a new method for introducing fluorine, future applications are anticipated in various fields。