ActivitiesAssociate Professor Nishikata develops a tertiary alkylation reaction by means of a copper catalyst and publishes the research in J. Am. Chem. Soc. (IF = 10.677) 2013.11.08

Takashi Nishikata, Associate Professor (tenure track) of Materials Science and Engineering at the Graduate School of Science and Engineering, and his group have successfully developed a “copper-catalyzed tertiary alkylation reaction” that uses easily decomposable α-halo carbonyl compounds, which until now have been difficult to use, as the source of tertiary alkyls. The group have also proved from analysis of the reaction mechanism that a radical is generated as an active species in the catalyzed elementary process of this reaction, and have successfully provided a theoretical interpretation of the reaction they have developed.

 This reaction is innovative in terms of being a method which can introduce a tertiary alkyl group in a single step, something which has conventionally required multiple steps, and is expected to find applications in the efficient synthesis of various useful products, including natural products.


 The achievement has been published in the Journal of the American Chemical Society (Takashi Nishikata,Yushi Noda, Ryo Fujimoto, and Tomomi Sakashita, J. Am. Chem. Soc., vol. 135, pp. 16372-16375). The Journal of the American Chemical Society is one of the top academic journals in the field of chemistry, with an IF (impact factor, the average number of citations per article) of 10.677.